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Views: 0 Author: Site Editor Publish Time: 2022-08-05 Origin: Site
Polygala is produced in Northeast, North, Northwest and Central China and Sichuan. It is a perennial herb with a stout taproot and a succulent phloem. Yuanzhi has the functions of calming the nerves, removing phlegm, and reducing swelling. It is used for insomnia, forgetfulness, palpitation, trance, unpleasant expectoration, sore, swollen poison, breast swelling and pain caused by heart and kidney failure.
1. Effects on the nervous system
(1) Sedative and anticonvulsant effects
Polygala radix root bark, whole root without Muxin removal and root Muxin have synergistic effects on barbiturates.
(2) The role of promoting physical strength and intelligence
(3) Anti-dementia and brain protective activity
2. Effects on the respiratory system
Polygala has an expectorant effect, but due to different experimental methods, its expectorant effect varies greatly. Using the mouse phenol red excretion method, the expectorant effect of Polygalaceae is stronger than that of Platycodon grandiflorum. Another scholar reported that 1g/kg Polygala decoction had no expectorant effect on anesthetized dogs by gavage. The study found that the chemical composition and pharmacological effects of the root bark of Polygala radix and root Muxin are not exactly the same. The saponin content of Polygala radix officinalis is only 4% of the root bark. The latter has no expectorant effect even when used at 50g/kg. It is speculated that the expectorant effect of Polygala Radix may be due to the stimulating effect of the saponins contained in it on the stomach membrane, which reflexively promotes the increase of bronchial secretions. The antitussive and expectorant effects of Shengyuanzhi and its decoctions on mice were observed by ammonia-induced cough method and colorimetric method. The results showed that: Sheng Yuanzhi, Mi Yuanzhi, Jiang Yuanzhi and Zhi (licorice) Yuanzhi had significant antitussive effects; the high dose of Sheng Yuanzhi, the low dose of Mi Yuanzhi, and the high dose of Zhi Yuanzhi also had obvious expectorant effect, antihypertensive effect.
3. The effect on central blood pressure
Polygala decoction has a short-term central antihypertensive effect. Intravenous injection of 100% Polygala decoction 0.125g/kg in anesthetized dogs can reduce blood pressure to 60-70% of the original level, and intravenous injection of 0.5g/kg in anesthetized rabbits can also reduce blood pressure to 40-50% of the original level. It is short-lived and can be restored to the original level within 1-2 minutes, and no rapid tolerance phenomenon is observed after repeated administration.
4. Effects on smooth muscle and cardiac muscle
In vitro and in vivo experiments show that Polygala has a strong excitatory effect on the uterus. The 100% injection prepared by ethanol precipitation of Yuanzhi water decoction has a strong excitatory and contractile effect on the isolated non-pregnant uterus of rats and mice. Polygala extract can make the pregnant and non-pregnant uterus of guinea pigs, rabbits, cats and dogs in vitro and in situ strongly contract and increase muscle tension. Intravenous injection of 6.6% Polygala decoction 3-6mL also has a significant stimulating effect on the eutopic uterus of pregnant dogs.
5. Diuretic effect
200mg/kg of the suspension prepared by cold immersion and concentration of Polygala Root in 50% methanol was orally administered to rats with edema caused by ligation of bilateral jugular veins. The rate is 100. Polygala saponins have the effect of eliminating edema and diuresis. If combined with phenylbutazone, its diuretic effect will be enhanced.
6. Antioxidant and anti-aging effects
D-galactose-induced aging mice were used to observe the effects of Yuanzhi decoction on the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in erythrocytes (RBC) of aging mice. The results showed that the water decoction of Polygala can significantly increase the activities of SOD and GSH-Px in the liver tissue of aging mice, suggesting that the decoction of Polygala has anti-aging effects on the aging mice, and the optimal medication time is 30 days.
7. Anti-mutation and anti-cancer effects
The Amse experiment found that the water-soluble extract of Polygonum polysaccharides has a significant inhibitory effect on the number of retromuted colonies induced by Aspergillus flavus B1, and has a significant inhibitory effect on the number of retromuted colonies of TA9 and strains, but has no inhibitory effect on the TAIo strain. It shows that the water-soluble extract of Polygonum orientalis only has mutation factors against base substitution.
8. Antibacterial effect
10% Polygala decoction has an inhibitory effect on Streptococcus pneumoniae by paper method, while Polygala ethanol infusion has obvious inhibitory effect on Gram-positive bacteria, Shigella, Typhi and Mycobacterium tuberculosis in vitro.
9. Inhibits alcohol absorption and hepatoprotective activity
The saponins in Polygala can inhibit the absorption of alcohol in the body to a certain extent.
10. Invigorating blood circulation and anti-inflammatory effect
The water extract of Polygala radix has preventive and therapeutic effects on 2,4,6-trinitrobenzenesulfonic acid-induced colitis in mice, and it can also prevent polymorphonuclear leukocyte infiltration in the distal colon of mice with colitis and erosive damage to the large intestine. It can significantly improve the symptoms of colonic mucosal cystic abscess and epithelial regeneration, and colonic weight gain, and can significantly reduce the contents of IFN-γ and IL-4 in small intestinal epithelial lymphocytes. At least in part due to its regulation of IFN-γ and IL-4 production.
In addition, the aqueous extract of Polygonum radix had significant effects on tumor necrosis factor-a (TNF-a) and interleukin-1 (IL-1) secreted by mouse astrocytes stimulated by P-substance and lipopolysaccharide (LPS). Inhibitory effect, which in turn produces anti-inflammatory activity on the central nervous system.
11. Hemolysis
In vitro test tube hemolysis shows that Polygala has a strong hemolytic effect. Its hemolytic index is 3926 for root bark, 2585 for whole root, 43 for root wood heart, and 34031 for purified saponin. The study found that the component of hemolysis is saponin, so the content of saponin is relatively high. The hemolytic effect of the more root bark part is much stronger than that of the root wood core part.
12. Other functions
In addition to the above effects, Polygalaceae also has the functions of promoting small intestinal motility, inhibiting aldo-ketone reductase, reducing cocaine-induced conditioned place preference, anti-vertigo, improving hearing impairment caused by membranous hydrops, and inhibiting 5-HT-induced diarrhea. .
1. People with yin deficiency and yang hyperactivity should not take it
Although it is said that this kind of Chinese herbal medicine has a certain effect of auxiliary diseases, it does not mean that everyone can take it. For example, there is a phenomenon of fire in the heart and kidney. The method to achieve the effect of assisting the disease will make our physical condition more serious.
2. People with gastric ulcer should not take it
I believe everyone knows that the traditional Chinese medicinal material of Yuanzhi will cause certain harm to gastric ulcers. If you have gastritis or gastric ulcers, it will cause serious harm, leading to the phenomenon of gastritis becoming more serious, and even possible It will cause the appearance of gastric cancer, so this group of people with gastric ulcers must use it less.
3. Long-term use can form dependence
Many people find that their sleep quality is not very good, so they choose to take Polygala to adjust the quality of sleep before going to bed. Although it has a certain effect, if it is taken for a long time, it may form a certain dependence. In addition, if you take it regularly, it will also lead to the development of intelligence, which will be affected to a certain extent, and will often appear unconscious.
