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Views: 0 Author: Site Editor Publish Time: 2022-07-18 Origin: Site
Pinellia, also known as Diwen, Shoutian, etc., belongs to Tiannan Xingmu. It is widely distributed in the Yangtze River Basin of China, as well as in Northeast and North China. Pinellia is a medicinal plant, which has the functions of drying dampness and resolving phlegm, reducing inversion and relieving vomiting, and for reducing boils and swelling.
1. Respiratory system
(1) Antitussive
The alkaloids in Pinellia sinensis can inhibit the cough center and produce an antitussive effect. Intravenous injection of the decoctions of raw Pinellia, Jiang Pinellia and French Pinellia has obvious antitussive effect on the cough caused by the injection of iodine into the thoracic cavity of cats or electrical stimulation of the superior laryngeal nerve, and the antitussive effect of 0.6g/kg is close to expected Because of 1mg/kg.
(2) expectorant
Intraperitoneal injection of Pinellia decoction in rats can significantly inhibit the secretion of pilocarpine on saliva. The ethanol extracts of Pinellia sinensis and Pinellia chinensis were given to mice by gavage. The ethanol extract of Pinellia chinensis had a certain expectorant effect by phenol red method, while Pinellia sinensis had no obvious effect. Zou Jilong and other studies have shown that the longer the storage time of Pinellia, the stronger the expectorant effect.
2. Digestive system effects
(1) Suppressing and inducing vomiting
Making Pinellia can activate the efferent activity of the vagus nerve and has an antiemetic effect, while raw Pinellia can "halberate the throat" and "make people vomit". Pinellia can prolong the incubation period of copper sulfate-induced vomiting in dogs or prevent vomiting, and can antagonize the vomiting of dogs with subcutaneous injection of hydrochloric acid dehydromorphine, which is not affected by Chuanwu.
(2) Anti-ulcer effect
Pinellia decoction and alcohol precipitation liquid can reduce gastric juice secretion, reduce free acidity and total acidity of gastric juice, inhibit pepsin activity, protect gastric mucosa, and promote gastric mucosal repair. The role of irritable ulcers.
(3) Effects on the liver and gallbladder
Pinellia can promote the secretion of bile in rabbits, increase the corticosterone in the blood of mice, enhance the induction of corticosterone on tyrosine transaminase in the liver, and increase the activity of tyrosine transaminase in the liver.
3. The role of the circulatory system
(1) Antiarrhythmic effect
Intravenous injection of Pinellia infusion to dogs can make ventricular premature beats caused by barium chloride disappear quickly without recurrence, and the effective rate is 97%. It can rapidly convert ventricular tachycardia caused by epinephrine to sinus rhythm with an effective rate of 96%.
(2) Anticoagulation
Pinellia has the effect of significantly reducing triglyceride and low-density lipoprotein, reducing whole blood viscosity, inhibiting the aggregation of red blood cells and improving the deformability of red blood cells. Pinellia protein is the only known protein with lectin function that only binds to mannitol but not to glucose. It has specific hemagglutination activity with rabbit erythrocytes, and it still has agglutination effect as low as 12μg/mL. In addition, Pinellia protein also has agglutination effect on red blood cells of sheep, dogs, cats, guinea pigs, rats, mice and pigeons, but no agglutination effect on red blood cells of humans, monkeys, pigs, chickens, ducks, toads, etc. Tip: The cell agglutination of Pinellia sinensis protein is not only species-specific but also cell-type specific.
4. Anti-tumor effect
In clinical practice, it has been reported that Pinellia has a good effect on the treatment of esophageal cancer, gastric cancer, tongue cancer, skin cancer and malignant lymphoma. Pinellia ternata extract has certain inhibitory effect on HeLa cells, experimental tumor 180 in mice, HCA solid tumor (liver cancer), and U14 (squamous epithelial cervical cancer transplanted into mice). Pinellia total alkaloids have inhibitory effect on chronic myeloid leukemia cells (K562), can damage the shape of K562 cells growing in suspension, and inhibit their proliferation.
The polysaccharides extracted from Pinellia sinensis have a strong activation activity of the reticuloendothelial system, which can enhance the phagocytosis and secretion of the reticuloendothelial system, and inhibit the occurrence and proliferation of tumors. The methanol-extracted Pinellia polysaccharide fraction has the ability to induce polymorphonuclear leukocytes. It is speculated that Pinellia may be a cellular reaction that leads to tumor destruction by activating polymorphonuclear leukocytes. Qin Zhifeng et al. applied traditional Chinese medicine Jinlongshe oral liquid and Shenmai injection to treat 35 patients with advanced gastric cancer. The results showed that the patients treated with traditional Chinese medicine had significantly increased physical strength index and natural killer (NK) cell activity, and two groups of tumor markers carcinoembryonic antigen. Compared with before treatment, C(CEA) and gastrointestinal cancer antigen (CA199) also decreased to a certain extent.
5. Anti-early pregnancy effect
Pinellia protein is considered to be one of the active ingredients or one of the active ingredients for anti-early pregnancy in Pinellia ternata. Subcutaneous injection of Pinellia protein 250μg to 7-day pregnant mice, 50% of the mice aborted, and no mice died. Pinellia protein 30mg/kg has obvious anti-early pregnancy effect on mice, and the anti-early pregnancy rate is as high as 100%. After 24 hours of administration, it can be seen that the level of plasma progesterone decreases, the endometrium becomes thinner, and the embryo stops developing.
