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Views: 0 Author: Site Editor Publish Time: 2022-07-15 Origin: Site
Polygala is a commonly used traditional Chinese medicine. Polygala added with honey is also called Miyuanzhi, which also has the effect of curing diseases. The main functions of Mi Yuanzhi are soothe the nerves and refresh the brain, strengthen the brain and improve intelligence, and reduce phlegm and swelling. Miyuanzhi belongs to the heart, lung, and kidney meridians, and has the functions of sedation, anti-convulsant, anti-dementia, and promotion of intellectual development. If you usually have insomnia, forgetfulness, trance, breast tenderness, you can take Miyuanzhi to relieve and improve. There are various saponins and polysaccharides in Miyuanzhi, so it has good antioxidant and neuron protection functions, and has a good therapeutic effect on Alzheimer's disease. In addition, Mi Yuanzhi can also protect the cardiovascular and cerebrovascular in certain aspects.
In general, the role of Miyuanzhi can be summarized as follows:
1. Effects on the nervous system
Sedative, anticonvulsant effect
Polygala radix root bark, whole root without Muxin removal and root Muxin have synergistic effects on barbiturates.
After oral administration of Polygala japonica extract to rats, active substances 3,4,5-trimethoxycinnamic acid (TMCA), methyl-3,4,5-trimethoxycinnamic acid (TMCA), methyl-3, 4,5-trimethoxycinnamic acid (MTMCA) and p-methoxycinnamic acid (PMCA), suggesting that the water extracts of Polygonum japonica contain the natural precursor drugs of TMCA. Further research was carried out on the active ingredient 3,4,5-trimethoxycinnamic acid (TMCA) in Polygala, and intraventricular injection of corticotropin-releasing hormone in rats could increase the content of norepinephrine in the locus coeruleus. It can be inhibited by intraventricular injection of TMCA, suggesting that TMCA may play a sedative effect by inhibiting the content of norepinephrine in the locus coeruleus. Its IC50 is comparable to that of papaverine.
Promotes physical and intellectual effects
Oral administration of 0.28 g/kg of Polygala japonica extract to rats was conducted to study the effect on shuttle behavior and brain regional metabolism. The results showed that 5-9 days after taking the drug, the number of conditioned reflexes and unconditioned reflexes increased, the concentration of coenzyme I (NAD) in the diencephalon was significantly increased, and the coenzyme I and reduced coenzyme I ( NADH) concentrations were increased, indicating that Polygala has the functions of strengthening the body and mind and enhancing the regional metabolism of the brain.
2. Effects on the respiratory system
Polygala has an expectorant effect, but due to different experimental methods, its expectorant effect varies greatly. Using the mouse phenol red excretion method, the expectorant effect of Polygalaceae is stronger than that of Platycodon grandiflorum.
3. The effect on central blood pressure
Polygala decoction has a short-term central antihypertensive effect. Intravenous injection of 100% Polygala decoction 0.125 g/kg in anesthetized dogs can reduce blood pressure to 60-70% of the original level, and intravenous injection of 0.5 g/kg in anesthetized rabbits can also reduce blood pressure to 40-50% of the original level, but the effect It is short-lived and can be restored to the original level within 1-2 minutes, and no rapid tolerance phenomenon is observed after repeated administration.
In clinical practice, Miyuanzhi is often used to treat the following diseases:
1. Miyuanzhi can be used for palpitation, insomnia, forgetfulness and other diseases. This medicine is bitter, pungent and warm. It not only improves the happy qi but calms the heart and soothes the mind, but also lowers the kidney qi and strengthens the mind without forgetting it. In the treatment of restless patients caused by heart-kidney discord, it can be combined with ginseng, dragon teeth and other drugs, such as Anshen Dingzhi Pill.
2. Miyuanzhi can also be used for phlegm cough, epilepsy, madness and other diseases. This medicine can not only expel phlegm, but also open orifice. In the treatment of patients with cough, thick phlegm, and unpleasant cough and vomiting, it is often used in combination with almonds, platycodon, etc.; in the treatment of patients with epilepsy and convulsions caused by phlegm blocking the heart orifices, it is often used in combination with Pinellia, Tianma and other drugs; In the treatment of patients with phlegm and mania, it is often used in combination with Shichangpu, turmeric and other drugs.
3. Miyuanzhi can also be used for carbuncle sore, breast carbuncle swelling and pain. This medicine can dispel the stagnation of qi and blood, dispel carbuncle and disperse swelling. In the treatment of carbuncle, regardless of the deficiency or excess of cold and heat, Miyuanzhi can be used to treat it.
Note on use: Excessive use of Miyuanzhi can easily lead to nausea and vomiting, so the general dosage is 3-10g; in addition, patients with gastritis and gastric ulcer should use it with caution.
Modern pharmacological studies have proved that Miyuanzhi has the effects of stimulating the uterus, hemolysis, sedation, hypnosis, anticonvulsant, expectorant, etc. In addition, it has inhibitory effects on Gram-positive bacteria, human Mycobacterium tuberculosis, Shigella, and Typhi. Modern application of Miyuanzhi compatibility, can treat insomnia, chronic fatigue syndrome, bronchitis cough, acute mastitis and other diseases.
